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    All donations are used to create better awareness of the need to advance the ethic in business and healthcare to meet evolving demands. This is done through numerous publications and educational services in a network of authors and researchers.

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  • An evolution that favours moral action more than mere survival and procreation. (5 minute read)

    We should all ask ourselves, is our survival and progress not dependent on an interlinked and progressive morality (more so than mere survival and reproductive strategies)? ‘The progressive development of the animal kingdom, and especially of mankind, is favoured much more by mutual support than by mutual struggle’. Peter Kropotkin, in Mutual Aid a factor of Evolution, 1902 Much has changed in the last two years and most certainly since Kropotkin published his work in 1902. Change seen, not only due to the Covid outbreak but due to advances in the biomedical sciences, society, its values and expectations. We are today thanks to a progressive science more than ever at the mercy of our DNA (a single strand of RNA emphasized this fact in 2020 with ongoing effect), how we assimilate and deploy such new understanding is entirely up to us. In an evolution driven by its quest for multiplication and procreation, we are but a species. We also know that we live in an interconnected world, where distrust and misinformation have become unwelcome realities of life and pose a significant challenge to both our current and future wellbeing. In genetics and biochemistry rapid progress in recent decades has led to a greater understanding of the chemical activity of proteins and their relation to the information stored in cellular DNA. Scientists were traditionally encouraged to develop an interpretation of biology that attempted simple solutions to the daunting convolutedness of nature. They saw living organisms as biochemical computers executing a molecular program. And they viewed that program as an algorithm encoded in genes and materialised by proteins. Within this blueprint-based framework, medical researchers focused on identifying the rogue genes and proteins that caused diseases, and on finding drugs to deactivate them. The problem with this reductionist approach was, and still often is, that it doesn’t consider how biological cells, organs, tumours and organisms entangle themselves with their environment, combining and recombining, and collectively using their structures at every scale (from the nanometre to the metre and beyond) to keep on living, evolving and surviving, in environments that are equally variable. To be fair, the reductionist approach to treating disease was justifiably fuelled by decades of revolutionary drug discoveries – antibiotics, chemotherapy and other ‘miracle drugs’ – that led to steep improvements in life expectancy but also brought along with it a new list of ailments, mostly seen in an escalating incidence of cancer, allergies and cardiovascular diseases. This century has seen a sharp decline in the number of effective new medicines produced. Literature states that between the years 2002 and 2014, a total of 71 new cancer drugs appeared, of which only 30 – found to prolong life in patients with solid tumours by an average of 2.1 months, compared with older drugs – have gained approval from the US Food and Drug Administration. The costly and largely ineffective trial-and-error methods used to identify new drugs, and the escalating complexity and difficulty of conducting clinical trials, are partly responsible for this downward turn. Undaunted by the dogmatism in molecular biology, many scientists in recent years started questioning the reductionist models of life and disease while turning their attention to how it genetically interacts in different environments. The capacity of biological organisms to evolve resistance to new treatments serves as one example of the inadequacy of a mere reductionist approach and also one of the most significant new public health concerns we face. We also now realise the chemically ridden world around us, in a climate that is also rapidly changing, will continue to complicate and plague any reductionist model inevitably now seen as driven by a more mobile DNA. Antibiotic resistance as an example has become one of the biggest public health threats to confront medical scientists, veterinarians and doctors; meanwhile, the ability of cancer cells to build defences against chemotherapy has stalled some overambitious pharmacologists searching for cancer cures. Bacteria and cancers on microbiological level are teaching us the same lesson that we are learning in other aspects of our relationship with nature. Clearly and almost to be expected, an evolutionary based life resists a reductionist approach. It relentlessly bounces back with complex behaviours that thwart our optimistic strategies to dominate it. Proteins are the building blocks of life. In nature, they result from the careful and deterministic folding of molecular strings consisting of combinations of 20 different units (the essential amino acids). They can take on any imaginable shape and function at the nanoscale. In fact, scientists still don’t know how many different proteins are in our bodies (perhaps it is unknowable), since our cells could have the capacity to create, modify and evolve proteins as and when they are needed. Proteins work as light detectors in our eyes, electrical switches in our neurons, nanowalkers in our muscles, and rotary nanomotors to catalyse chemical reactions. They are responsible for detecting and reacting to the signals, forces and information from the environment in which an organism resides and interconnects to, and also for creating the structures that allow movement, the extraction of energy from food or the destruction of pathogens. No human-made artificial technology can dream of such capacities. We can however try to learn how life does it, and continuously progress in in our understanding while responsibly employing this new knowledge in a responsible manner. One of the essential features of all life is having some method or methods to be perceptive of change around it and relay such input to its DNA. It has to constantly prepare and be able to function while facing uncertainties and unknows in challenging environments. It has to have a memory of what it learnt in the past that can serve across generations. Evolution, and all the chemistry it is made up of, interact and is witnessed in emerging science as having this ability, and it does so in a principled manner. Without biases, life (evolution) on all levels, interconnect and perceive information from its surroundings to evolve a reliable physical sphere of existence—not only to survive but to better interconnect in full regard of even its smallest components. It must gather reliable information to prepare for unknowns in an uncertain future based on its perceptions of a changeable and challenging environments. It is when these interactive spheres get hijacked by unreliable information or biases that we get confused and face a precarious future. We can only remedy this when, and if, we become perceptive of and have access to reliable information. The more progressive our perceptions and this information and knowledge become, the more important the value of fairness and mutual support also become. It is by harmonising and operating wisely in reliably interconnected spheres of perception without biases in any of the three spheres (physical reality, uncertainty and the unknown) that we can confidently prepare ourselves for the future. And it can only be when we measure our progress in terms of the morality of our actions in this newly gained knowledge, that a much better world will become a reality for all of us. Theodore Holtzhausen, author of Spheres of Perception Blog article, 10/4/2021

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  • Help needed, we are creating a better future

    ABOUT ​ A significant paradigm shift occurred in recent years in our understanding of how a genetic life emerged on Earth. Simultaneously, in astrophysics the concept of our place in the universe has been redefined. It created a much different picture of how life interconnects to the environment and our place and purpose in it. ​ Spilling into healthcare and ecology, we are able to now better heal, nurture and fine-tune our DNA by caring for our epigenome (the network of chemical compounds surrounding DNA that can modify the genome). This created better understanding of how we interconnect with our world and environment. We are standing on the edge of an era of genomics and cyborgs... in a yet unimagined new world. ​ Redefining a living interconnected network perceptive of change on all levels , we need to increase awareness of how healthcare and social development programs must be based on open, yet principled, interactions to face the future. From cellular level to complex social networks this demands improving and enriching our environments and abolishing poverty and inequality. It emphasises the value of organisations contributing to preventing disease by eliminating stress caused by mental and toxic environmental factors and corruption. Above all it must operate under a sound, reliable and universally acceptable ethic. By seeing the genome as part of a living and network, we promote better understanding of this consonance. Our work has no cultural, racial, species or social boundaries, or any religious or institutionalised affiliations. We are committed to reduce suffering, fight corruption, reduce poverty and promote moral conduct, equality and healthy living. We want to ensure all the advances of new technology and genitc medicine will reach an interconnected global community —fairly. ​ CONTACT US epigenome perceptive of change on all levels {Spheres of Perception is an affiliation of Sensible Gene Ltd New Zealand}

  • Spheres of Perception

    NEW IDEAS CHANGE THE WORLD HEALTH & GENOMICS COMMUNITY ISSUES ENVIRONMENT & CLIMATE CHANGE OUR MISSION ENDORSEMENTS Latest Blog Articles Join our forums, it's free Please NOTE, this site is entirely dedicated to find workable solutions for harmonious social change, any extremist, political or religious opinions will be blocked and deleted. EPIDEMIC UPDATES... Spheres of Perception is Affiliated to Sensible Gene Ltd New Zealand Privacy and Terms of Use

  • Links and Updates | SpheresofPerceptionSpheres of PerceptionTheodore HoltzhausenLinks and Updates Spheres of Perception

    At first glance, the Cornish mallow (Lavatera cretica) is little more than an unprepossessing weed. It has pinkish flowers and broad, flat leaves that track sunlight throughout the day. However, it’s what the mallow does at night that has propelled this humble plant into the scientific spotlight. Hours before the dawn, it springs into action, turning its leaves to face the anticipated direction of the sunrise. The mallow seems to remember where and when the Sun has come up on previous days, and acts to make sure it can gather as much light energy as possible each morning. When scientists try to confuse mallows in their laboratories by swapping the location of the light source, the plants simply learn the new orientation. What does it even mean to say that a mallow can learn and remember the location of the sunrise? The idea that plants can behave intelligently, let alone learn or form memories, was a fringe notion until quite recently. Memories are thought to be so fundamentally cognitive that some theorists that they’re a necessary and sufficient of whether an organism can do the most basic kinds of thinking. Surely memory requires a brain, and plants lack even the rudimentary nervous systems of bugs and worms. argue marker However, over the past decade or so this view has been forcefully challenged. The mallow isn’t an anomaly. Plants are not simply organic, passive automata. We now know that they can sense and integrate information about dozens of different environmental variables, and that they use this knowledge to guide flexible, adaptive behaviour. For example, plants can whether nearby plants are kin or unrelated, and adjust their foraging strategies accordingly. The flower Impatiens pallida, also known as pale jewelweed, is one of several species that tends to devote a greater share of resources to growing leaves rather than roots when put with strangers – a tactic apparently geared towards competing for sunlight, an imperative that is diminished when you are growing next to your siblings. Plants also mount complex, targeted in response to recognising . The small, flowering Arabidopsis thaliana, also known as thale or mouse-ear cress, can detect the vibrations caused by caterpillars munching on it and so release oils and chemicals to repel the insects. recognise defences specific predators Plants also communicate with one another and , such as parasites and microbes, using a variety of – including ‘mycorrhizal networks’ of fungus that link up the root systems of multiple plants, like some kind of subterranean internet. Perhaps it’s not really so surprising, then, that plants learn and use memories for prediction and decision-making. other organisms channels Sign up to our newsletter Updates on everything new at Aeon. DailyWeekly See our newsletter privacy policy here What does learning and memory involve for a plant? An example that’s front and centre of the debate is vernalisation, a process in which certain plants must be exposed to the cold before they can flower in the spring. The ‘memory of winter’ is what helps plants to distinguish between spring (when pollinators, such as bees, are busy) and autumn (when they are not, and when the decision to flower at the wrong time of year could be reproductively disastrous). In the biologists’ favourite experimental plant, A thaliana, a gene called FLC produces a chemical that stops its little white blooms from opening. However, when the plant is exposed to a long winter, the by-products of other genes measure the length of time it has been cold, and close down or repress the FLC in an increasing number of cells as the cold persists. When spring comes and the days start to lengthen, the plant, primed by the cold to have low FLC, can now flower. But to be effective, the anti-FLC mechanism needs an extended chilly spell, rather than shorter periods of fluctuating temperatures. This involves what’s called epigenetic memory. Even after vernalised plants are returned to warm conditions, FLC is kept low via the remodelling of what are called chromatin marks. These are proteins and small chemical groups that attach to DNA within cells and influence gene activity. Chromatin remodelling can even be transmitted to subsequent generations of divided cells, such that these later produced cells ‘remember’ past winters. If the cold period has been long enough, plants with some cells that never went through a cold period can still flower in spring, because the chromatin modification continues to inhibit the action of FLC. But is this really memory? Plant scientists who study ‘epigenetic memory’ will be the first to admit that it’s fundamentally different from the sort of thing studied by cognitive scientists. Is this use of language just metaphorical shorthand, bridging the gap between the familiar world of memory and the unfamiliar domain of epigenetics? Or do the similarities between cellular changes and organism-level memories reveal something deeper about what memory really is? Both epigenetic and ‘brainy’ memories have one thing in common: a persistent change in the behaviour or state of a system, caused by an environmental stimulus that’s no longer present. Yet this description seems too broad, since it would also capture processes such as tissue damage, wounding or metabolic changes. Perhaps the interesting question isn’t really whether or not memories are needed for cognition, but rather which types of memories indicate the existence of underlying cognitive processes, and whether these processes exist in plants. In other words, rather than looking at ‘memory’ itself, it might be better to examine the more foundational question of how memories are acquired, formed or learned. When the plant was dropped from a height, it learned that this was harmless and didn’t demand a folding response ‘The plants remember,’ said the behavioural ecologist Monica Gagliano in a recent radio , ‘they know exactly what’s going on.’ Gagliano is a researcher at the University of Western Australia, who studies plants by applying behavioural learning techniques developed for animals. She reasons that if plants can produce the results that lead us to believe other organisms can learn and remember, we should similarly conclude that plants share these cognitive capacities. One form of learning that’s been studied extensively is habituation, in which creatures exposed to an unexpected but harmless stimulus (a noise, a flash of light) will have a cautionary response that slowly diminishes over time. Think of entering a room with a humming refrigerator: it’s initially annoying, but usually you’ll get used to it and perhaps not even notice after a while. True habituation is stimulus-specific, so with the introduction of a different and potentially dangerous stimulus, the animal will be re-triggered. Even in a humming room, you will probably startle at the sound of a loud bang. This is called dishabituation, and distinguishes genuine learning from other kinds of change, such as fatigue. interview In 2014, Gagliano and her colleagues the learning capacities of a little plant called Mimosa pudica, a creeping annual also known as touch-me-not. Its name comes from the way its leaves snap shut defensively in response to a threat. When Gagliano and her colleagues dropped M pudica from a height (something the plant would never have encountered in its evolutionary history), the plants learned that this was harmless and didn’t demand a folding response. However, they maintained responsiveness when shaken suddenly. Moreover, the researchers found that M pudica’s habitation was also context-sensitive. The plants learnt faster in low-lit environments, where it was more costly to close their leaves because of the scarcity of light and the attendant need to conserve energy. (Gagliano’s research group was not the first to apply behavioural learning to plants such as M pudica, but earlier studies were not always well-controlled so findings were inconsistent.) tested approaches But what about more complex learning? Most animals are also capable of conditioned or associative learning, in which they figure out that two stimuli tend to go hand in hand. This is what allows you to train your dog to come when you whistle, since the dog comes to associate that behaviour with treats or affection. In another , published in 2016, Gagliano and colleagues tested whether Pisum sativum, or the garden pea, could link the movement of air with the availability of light. They placed seedlings at the base of a Y-maze, to be buffeted by air coming from only one of the forks – the brighter one. The plants were then allowed to grow into either fork of the Y-maze, to test whether they had learned the association. The results were positive – showing that the plants learned the conditioned response in a situationally relevant manner. study The evidence is mounting that plants share some of the treasured learning capacities of animals. Why has it taken so long to figure this out? We can start to understand the causes by running a little experiment. Take a look at this image. What does it depict? Figure 1: ‘Leaping Laelaps’ (1897) by Charles Robert Knight. Courtesy Wikipedia. Most people will respond either by naming the general class of animals present (‘dinosaurs’) and what they are doing (‘fighting’, ‘jumping’), or if they are dinosaur fans, by identifying the specific animals (‘genus Dryptosaurus’). Rarely will the mosses, grasses, shrubs and trees in the picture get a mention – at most they might be referred to as the background or setting to the main event, which comprises the animals present ‘in a field’. In 1999, the biology educators James Wandersee and Elisabeth Schussler this phenomenon plant blindness – a tendency to overlook plant capacities, behaviour and the unique and active environmental roles that they play. We treat them as part of the background, not as active agents in an ecosystem. called Some reasons for plant blindness are historical – philosophical hangovers from long-dismantled paradigms that continue to infect our thinking about the natural world. Many researchers still write under the influence of Aristotle’s influential notion of the scala naturae, a ladder of life, with plants at the bottom of the hierarchy of capacity and value, and Man at the peak. Aristotle emphasised the fundamental conceptual divide between immobile, insensitive plant life, and the active, sensory realm of animals. For him, the divide between animals and humankind was just as stark; he didn’t think animals thought, in any meaningful way. After the reintroduction of such ideas into Western European education in the early 1200s and throughout the Renaissance, Aristotelean thinking has remained remarkably persistent. It’s often adaptive for humans to treat plants as object-like, or simply filter them out Today, we might call this systematic bias against non-animals zoochauvinism. It’s well-documented in the , in biology , in publication trends, and media representation. Furthermore, children growing up in cities tend to to plants through interactive observation, plant care, and a situated plant appreciation and knowledge by acquaintance. education system textbooks lack exposure Particularities of the way our bodies work – our perceptual, attentional and cognitive systems – contribute to plant blindness and biases. Plants don’t usually jump out at us suddenly, present an imminent threat, or behave in ways that obviously impact upon us. show that they aren’t detected as often as animals, they don’t capture our attention as quickly, and we forget them more readily than animals. It’s often adaptive to treat them as object-like, or simply filter them out. Furthermore, frequently involves chemical and structural changes that are simply too small, too fast or too slow for us to perceive without equipment. Empirical findings plant behaviour As we are animals ourselves, it’s also easier for us to recognise animal-like behaviour as behaviour. Recent findings in robotics indicate that human participants are more likely to attribute properties such as , intentionality and to systems when those systems conform to or human-like behaviour. It seems that, when we’re deciding whether to interpret behaviour as intelligent, we rely on anthropomorphic prototypes. This helps to explain our intuitive reluctance to attribute cognitive capacities to plants. emotion behaviour animal But perhaps prejudice is not the only reason that plant cognition has been dismissed. Some theorists worry that concepts such as ‘plant memory’ are nothing but . When we try to apply cognitive theory to plants in a less vague way, they say, it seems that plants are doing something quite unlike animals. Plant mechanisms are complex and fascinating, they agree, but not cognitive. There’s a concern that we’re defining memory so broadly as to be meaningless, or that things such as habituation are not, in themselves, cognitive mechanisms. obfuscating metaphors One way of probing the meaning of cognition is to consider whether a system trades in representations. Generally, representations are states that are about other things, and can stand in for those things. A set of coloured lines can form a picture representing a cat, as does the word ‘cat’ on this page. States of the brain are also generally taken to represent parts of our environment, and so to enable us to navigate the world around us. When things go awry with our representations, we might represent things that aren’t there at all, such as when we hallucinate. Less drastically, sometimes we get things slightly wrong, or misrepresent, parts of the world. I might mishear lyrics in amusing ways (sometimes called ‘mondegreens’), or startle violently thinking that a spider is crawling on my arm, when it’s only a fly. The capacity to get it wrong in this way, to misrepresent something, is a good indication that a system is using information-laden representations to navigate the world; that is, that it’s a cognitive system. When we create memories, arguably we retain of some of this represented information for later use ‘offline’. The philosopher Francisco Calvo Garzón at the University of Murcia in Spain has that, for a physical state or mechanism to be representational, it must ‘stand for things or events that are temporarily unavailable’. The capacity for representations to stand in for something that’s not there, he claims, is the reason that memory is taken to be the mark of cognition. Unless it can operate offline, a state or mechanism is not genuinely cognitive. argued The mallow learns a new location when plant physiologists mess with its ‘head’ by changing the light’s direction On the other hand, some theorists allow that certain representations can only operate ‘online’ – that is, they represent and track parts of the environment in real time. The mallow’s nocturnal capacity to predict where the Sun will rise, before it even appears, seems to involve ‘offline’ representations; other heliotropic plants, which track the Sun only while it is moving across the sky, arguably involve a kind of ‘online’ representation. Organisms that use only such online representation, theorists say, might still be cognitive. But offline processes and memory provide stronger evidence that organisms are not just responding reflexively to their immediate environment. This is particularly important for establishing claims about organisms that we are not intuitively inclined to think are cognitive – such as plants. Is there evidence that plants do represent and store information about their environment for later use? During the day, the uses motor tissue at the base of its stalks to turn its leaves towards the Sun, a process that’s actively controlled by changes in water pressure inside the plant (called turgor). The magnitude and direction of the sunlight is encoded in light-sensitive tissue, spread over the mallow’s geometric arrangement of leaf veins, and stored overnight. The plant also tracks information about the cycle of day and night via its internal circadian clocks, which are sensitive to environmental cues that signal dawn and dusk. mallow Overnight, using information from all these sources, the mallow can predict where and when the Sun will rise the next day. It might not have concepts such as ‘the Sun’ or ‘sunrise’, but it stores information about the light vector and day/night cycles that allows it to reorient its leaves before dawn so that their surfaces face the Sun as it climbs in the sky. This also allows it to re-learn a new location when plant physiologists mess with its ‘head’ by changing the direction of the light source. When the plants are shut in the dark, the anticipatory mechanism also works offline for a few days. Like other foraging strategies, this is about optimising available resources – in this case, sunlight. Does this mechanism count as a ‘representation’ – standing in for parts of the world that are relevant to the plant’s behaviour? Yes, in my view. Just as neuroscientists try to uncover the mechanisms in nervous systems in order to understand the operation of memory in , plant research is beginning to unravel the memory substrates that allow plants to store and access information, and use that memory to guide behaviour. animals Plants are a diverse and flexible group of organisms whose extraordinary capacities we are only just beginning to understand. Once we expand the vista of our curiosity beyond animal and even plant – to look at fungi, bacteria, protozoa – we might be surprised to find that many of these organisms share many of the same basic behavioural strategies and principles as us, including the capacity for kinds of learning and memory. kingdoms To make effective progress, we need to pay careful attention to plant mechanisms. We need to be clear about when, how and why we are using metaphor. We need to be precise about our theoretical claims. And where the evidence points in a direction, even when it is away from common consensus, we need to boldly follow where it leads. These research programmes are still in their infancy, but they will no doubt continue to lead to new discoveries that challenge and expand human perspectives on plants, blurring some of the traditional boundaries that separated the plant and animal realms. Of course, it’s a stretch of the imagination to try to think about what thinking might even mean for these organisms, lacking as they do the brain(mind)/body(motor) divide. However, by pushing ourselves, we might end up expanding the concepts – such as ‘memory’, ‘learning’ and ‘thought’ – that initially motivated our enquiry. Having done so, we see that in many cases, talk of plant learning and memory is not just metaphorical, but also matter-of-fact. Next time you stumble upon a kerbside mallow bobbing in the sunlight, take a moment to look at it with new eyes, and to appreciate the window this little weed provides into the extraordinary cognitive capacities of plants. https://aeon.co/essays/beyond-the-animal-brain-plants-have-cognitive-capacities-too?utm_source=Aeon+Newsletter&utm_campaign=87a007a27a-EMAIL_CAMPAIGN_2021_03_29_02_58&utm_medium=email&utm_term=0_411a82e59d-87a007a27a-70379153

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